Radiation-induced xerostomia is caused by the direct damaging effects of radiation on both major and minor salivary gland structures located in the radiation path.
Glandular tissue in general is very sensitive to radiation. Following radiation therapy, the mouth becomes dry as a result of the loss of salivary gland acini. The skin becomes dry as well because of loss of sweat and sebaceous glands.
Ductal epithelium is somewhat radiation resistant.
Glandular tissue in general is very sensitive to radiation. Following radiation therapy, the mouth becomes dry as a result of the loss of salivary gland acini. The skin becomes dry as well because of loss of sweat and sebaceous glands.
Ductal epithelium is somewhat radiation resistant.
Because most radiation ports leave some areas of mucosa untouched, there is an opportunity to stimulate the remaining glands to overproduce.
Although they improve mouth moisture in only about 70% of irradiated patients,
pilocarpine (Salagen, MGI Pharma), 5 mg by mouth three times daily, or
cevimeline (Evoxac, Daiichi Sankyo), 30 mg by mouth three times daily, often improves eating, speaking, and swallowing functions.
It must be given with caution to individuals with heart diseases associated with brachycardia, heart block, or medications such as beta blockers that may slow heart rate or conduction.
Additionally, sports water bottles are used by many individuals, and Evian atomized water spray has been found to be beneficial to many.
KABOOM XERO STICKS™ are clinically proven to Improve Oral Health and can have life changing effects on patients
ReplyDeletesuffering with Dry Mouth
xerostomia